ChloroquineV1, Main, Exploration, bibRecord, 003886

Differential effects of chloroquine and of several other amphiphilic cationic drugs upon rat choroid plexus

Identifieur interne : 003886 ( Main/Exploration ); précédent : 003885; suivant : 003887

Differential effects of chloroquine and of several other amphiphilic cationic drugs upon rat choroid plexus

Auteurs : W. Frisch [Allemagne] ; R. Lüllmann-Rauch [Allemagne]

Source :

Acta Neuropathologica [ 0001-6322 ] ; 1979-01-01.

RBID : ISTEX:FB4C7C3BE79E322E19FC1A5AE4A0497385FEFE80

English descriptors

KwdEn :
- Chloroquine, Chlorphentermine, Choroid plexus, Lipidosis, Rat.
Teeft :
- Acta, Acta neuropathol, Amphiphilic, Amphiphilic cationic drugs, Antidepressant, Cationic, Chloroquine, Chlorphentermine, Choroid, Choroid plexus, Choroid plexus epithelium, Cytoplasmic, Cytoplasmic vacuolation, Cytoplasmic vacuoles, Dense cytoplasmic inclusions, Epithelial, Epithelial cells, Epithelium, Flocculent material, Generalized lipidosis, Higher magnification, Inclusion, Ivth ventricle, Lamellar, Lamellated, Lateral ventricles, Levine, Lipid, Lipidosis, Lysosomal, Lysosomal storage, Neuropathol, Other drugs, Plexus, Polar lipids, Present study, Quinacrine, Tricyclic antidepressants, Vacuolation, Vacuole.

Abstract

Summary: Several cationic amphiphilic drugs, each of which is known to induce generalized lipidosis in rats, were compared with respect to their cytological effects on rat choroid plexus epithelium. Chloroquine induced large cytoplasmic vacuoles, whereas the other drugs (quinacrine, 4,4′-diethylaminoethoxyhexestrol, chlorphentermine, iprindole, 1-chloro-amitriptyline, clomipramine) caused formation of lamellated or crystalloid inclusions as usually seen in drug-induced lipidosis. The ultrastructure of the chloroquine-induced vacuoles suggested storage of water-soluble materials (polar lipids and/or non-lipid materials) in addition to non-water-soluble polar lipids.

Url:

https://api.istex.fr/ark:/67375/1BB-6XG3CJHJ-N/fulltext.pdf

DOI: 10.1007/BF00690845

Affiliations:

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Le document en format XML

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<term>Chlorphentermine</term>
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<term>Lipidosis</term>
<term>Rat</term>
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<keywords scheme="Teeft" xml:lang="en"><term>Acta</term>
<term>Acta neuropathol</term>
<term>Amphiphilic</term>
<term>Amphiphilic cationic drugs</term>
<term>Antidepressant</term>
<term>Cationic</term>
<term>Chloroquine</term>
<term>Chlorphentermine</term>
<term>Choroid</term>
<term>Choroid plexus</term>
<term>Choroid plexus epithelium</term>
<term>Cytoplasmic</term>
<term>Cytoplasmic vacuolation</term>
<term>Cytoplasmic vacuoles</term>
<term>Dense cytoplasmic inclusions</term>
<term>Epithelial</term>
<term>Epithelial cells</term>
<term>Epithelium</term>
<term>Flocculent material</term>
<term>Generalized lipidosis</term>
<term>Higher magnification</term>
<term>Inclusion</term>
<term>Ivth ventricle</term>
<term>Lamellar</term>
<term>Lamellated</term>
<term>Lateral ventricles</term>
<term>Levine</term>
<term>Lipid</term>
<term>Lipidosis</term>
<term>Lysosomal</term>
<term>Lysosomal storage</term>
<term>Neuropathol</term>
<term>Other drugs</term>
<term>Plexus</term>
<term>Polar lipids</term>
<term>Present study</term>
<term>Quinacrine</term>
<term>Tricyclic antidepressants</term>
<term>Vacuolation</term>
<term>Vacuole</term>
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<front><div type="abstract" xml:lang="en">Summary: Several cationic amphiphilic drugs, each of which is known to induce generalized lipidosis in rats, were compared with respect to their cytological effects on rat choroid plexus epithelium. Chloroquine induced large cytoplasmic vacuoles, whereas the other drugs (quinacrine, 4,4′-diethylaminoethoxyhexestrol, chlorphentermine, iprindole, 1-chloro-amitriptyline, clomipramine) caused formation of lamellated or crystalloid inclusions as usually seen in drug-induced lipidosis. The ultrastructure of the chloroquine-induced vacuoles suggested storage of water-soluble materials (polar lipids and/or non-lipid materials) in addition to non-water-soluble polar lipids.</div>
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<name sortKey="Lullmann Rauch, R" sort="Lullmann Rauch, R" uniqKey="Lullmann Rauch R" first="R." last="Lüllmann-Rauch">R. Lüllmann-Rauch</name>
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Differential effects of chloroquine and of several other amphiphilic cationic drugs upon rat choroid plexus

Differential effects of chloroquine and of several other amphiphilic cationic drugs upon rat choroid plexus

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri